Bcl-2 turns deadly

When a healthy diet turns deadly

The health benefits of a high fiber diet (HFD) result in part from the action of metabolic end products made by gut commensals on the host epithelium. Butyrate is one such beneficial metabolite; however, butyrate paradoxically enhances the capacity of Escherichia coli-produced Shiga toxin type 2 (Stx2) to kill tissue culture cells. We recently showed that mice fed an HFD exhibited increased but...

When Fatigue Turns Deadly: The Association Between Fatigue and Racial Bias in the Decision to Shoot

Racial bias in the decision to shoot can be minimized if individuals have ample cognitive resources to regulate automatic reactions. However, when individuals are fatigued, cognitive control may be compromised, which can lead to greater racial bias in shoot/ don’t-shoot decisions. The current studies provide evidence for this hypothesis experimentally using undergraduate participants (Study 1) ...

Bcl-2

Recent findings from our laboratory provide the first indication that overexpression of Bcl-2 in Eµ-myc transgenic cells enhances tumor immunosurveillance by inducing NKG2D ligands. Initial evidence suggests that this model is relevant to human patients. Thus, antitumor therapies that target Bcl-2 harbor the risk of reducing tumor immunogenicity.

BCL 2 L 11 ( BCL 2 - like 11 ( apoptosis facilitator ) )

Other names: BAM, BIM, BIM-alpha6, BIM-beta6, BIM-beta7, BOD, BimEL, BimL HGNC (Hugo): BCL2L11 Location: 2q13 Local order: According to GeneLoc and NCBI Map Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the B...

SnapShot: BCL-2 Proteins